Model Overview

Our Liver-Chip recreates true-to-life functions of the liver and is available in three different cell configurations: co-culture, tri-culture, and quad-culture. Our human Liver-Chip incorporates relevant extracellular matrix (ECM) interactions, a hepatocyte and liver sinusoidal endothelial cell interface, along with relevant cyto-architecture, and physiological flow.

 
 
 
 

 

Configurations

Our Human Liver-Chip can be set up into various configurations using our approved protocols, depending on study requirements — including co-, tri-, and quad-culture.

 
 
co-culture copy.jpg

Co-Culture

hepatocytes + LSECs

tri-culture copy.jpg

Tri-Culture

Co-Culture + Kupffer cells

quad-culture copy.jpg

Quad-Culture

Tri-Culture + stellate cells


Applications


Our Liver-Chip demonstrates in vivo-relevant responses to known and tool compounds at clinically relevant concentrations and through the appropriate mechanisms of action.

General Toxicity · Mechanistic Toxicity · Nutrient Metabolism


 
products.png

Liver Bio-Kit

Our Human Liver-Chip is currently available as a complete kit including Organ-Chips, cells, reagents, training, and support from our team of experts. For more information about kit options and pricing, contact us below.

 
services.png

Liver Services

We offer services run on our Liver-Chips to deliver clinically-relevant, decision-worthy insights. Our experienced services team is ready to design and execute studies with your desired endpoints in mind.

 

Resources

 
 

PROTOCOLS

Protocols developed by our experts guide the process of Liver-Chip culture and analysis.