Due to the distinct structure and biology of different parts of the lung and their differentiated role in disease processes, we are developing a range of Lung-Chips to enable human-relevant research related to lung diseases and various aspects of lung biology.
The Alveolus Lung-Chip emulates fundamental lung functions of the alveolus, such as gas exchange and absorption. It has been used in a range of applications, including evaluation of nanoparticle absorption and toxicity, study of disease development, and assessment of adverse drug effects, such as pulmonary edema and pulmonary thrombosis.
The Airway Lung-Chip recapitulates the physiology and function of the airway epithelium, which conducts inhaled air to the alveolar air sacs. Research done by our scientists and with our collaborators has demonstrated that the Airway Lung-Chip models inflammation and therapeutic responses that are typical of human small airway diseases, including asthma and chronic obstructive pulmonary disease (COPD).
While our Lung-Chip is undergoing development, we offer guidelines to inform the process of Lung-Chip culture.