Organ-Chips and organoids are technologies that can be used together. Organoids provide a robust cell source that contain all of the key cell types of the tissue of interest at physiologically relevant ratios.
Our data has shown that organoids in Organ-Chips offer a significant improvement in functional endpoints and show a transcriptomic profile closer to in vivo than organoids alone. Combining Organ-Chips and organoids also overcomes some of the challenges associated with organoids, for example, the lack of mechanical forces and lack of flow (dynamic microenvironment).
Patient-derived organoids in Organ-Chips can also enable human-relevant disease modeling.
Below are publications that have combined our Organs-on-Chips technology with organoids.
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To learn how you can use organoids as a cell source for our Organ-Chips, click below to get in touch with our team.